According to an animal study from the Icahn School of Medicine at Mount Sinai, a polyphenol preparation made from Concord grape juice, grape seed extract and trans-resveratrol has show a lot of promise for treating depression.
“Two phytochemicals in particular — dihydrocaffeic acid (DHCA) and malvidin-3′-O-glucoside (Mal-gluc) — appeared to be responsible for the beneficial effects, which included modulating inflammation and synaptic plasticity, essentially increasing resilience against stress-induced depression in mice.2
Previous research has found that a single dose of resveratrol can improve blood flow to your brain and may enhance several aspects of brain function, including lowered inflammation that may extend to protection against depression.3 The featured study revealed that the grape-derived compounds target cellular and molecular pathways associated with inflammation while modulating synaptic plasticity, disruptions of which have been linked to depression.”
Many other grapes that contain the compound resveratrol can be found in mulberries, raspberries, pomegranates, red wine and even dark chocolate. These other sources have shown to have antidepressant effects in rats and mice.
There are many other supplements useful for Depression such as Psilocybin, Magnesium, Omega-3 fats, B Vitamins, Folate and Probiotics.
“Grape-Derived Compounds to Help Beat Depression” by Dr. Mercola